. 2010 Dec 3;22(6):1413–1419. doi: 10.1093/annonc/mdq599

Table 4.

Percent changes from baseline in IAUC₆₀ and K^trans on days 2, 8 and 26

DCE-MRI parameter	Study day	Percent change from baseline point estimate (95% CI)
DCE-MRI parameter	Study day	320 mg	800 mg C	800 mg I	400 mg b.i.d.
IAUC₆₀, % (95% CI)	2	−4 (–23 to +19)	−28^a (−46 to −8)^a	−36^a (−56 to −7)	−20^a (−50 to +28)
	8	−4 (−28 to +19)	−37^a (−51 to −19)	−27 (−50 to +7)	−64^a (−78 to −42)
	26	−3 (−22 to +21)	−47^a (−60 to −30)	−29 (−53 to +5)	−57^a (−74 to −30)
K^trans (95% CI)	2	−4 (−24 to +21)	−31^a (−49 to −9)^a	−44^a (−63 to −16)	−31 (−58 to +15)
	8	−6 (−25 to +17)	−45^a (−59 to −26)	−31 (−54 to +5)	−64^a (−78 to −39)
	26	−6 (−26 to +18)	−51^a (−65 to −32)	−34 (−58 to +2)	−59^a (−76 to −31)

Statistically significant differences from baseline (P < 0.017).

CI, confidence interval; DCE-MRI, dynamic contrast-enhanced magnetic resonance imaging; C, continuous; I, intermittent; IAUC₆₀, area under the plasma concentration–time curve for the first 60 s postcontrast agent injection; K^trans, transfer constant.