Table 3.
Distribution of 5922 cases of pancreatic cancer and 11 062 controlsa, OR and corresponding 95% CI according to smoking of different tobacco products and their combinations
| Cases, n (%) | Controls, n (%) | ORb (95% CI) | |
| Never tobacco users | 2131 (36.0) | 4599 (41.6) | 1 |
| Cigarette-only smokers | 3075 (51.9) | 5149 (46.6) | 1.50 (1.39–1.62) |
| Cigar-only smokers | 64 (1.1) | 112 (1.0) | 1.62 (1.15–2.29) |
| Grams of tobacco/dayc | |||
| Never tobacco smokers | 1255 (96.5) | 3570 (97.4) | 1 |
| <10 | 22 (1.7) | 64 (1.7) | 1.20 (0.71–2.01) |
| ≥10 | 16 (1.2) | 27 (0.7) | 1.82 (0.93–3.55) |
| Missing | 8 (0.6) | 6 (0.2) | |
| χ2 trend; P-value | 3.29; 0.07 | ||
| Duration (years)d | |||
| Never tobacco smokers | 1477 (96.6) | 3768 (97.3) | 1 |
| <20 | 25 (1.6) | 46 (1.2) | 1.39 (0.82–2.37) |
| ≥20 | 26 (1.7) | 57 (1.5) | 1.39 (0.83–2.32) |
| Missing | 1 (0.1) | – | |
| χ2 trend; P-value | 2.66; 0.10 | ||
| Pipe-only smokers | 38 (0.6) | 99 (0.9) | 1.06 (0.69–1.63) |
| Grams of tobacco/dayc | |||
| Never tobacco smokers | 1255 (98.3) | 3570 (97.8) | 1 |
| <10 | 11 (0.9) | 41 (1.1) | 0.92 (0.46–1.86) |
| ≥10 | 11 (0.9) | 40 (1.1) | 0.78 (0.38–1.61) |
| Missing | – | 1 (0.0) | |
| χ2 trend; P-value | 0.48; 0.49 | ||
| Duration (years)d | |||
| Never tobacco smokers | 1477 (98.1) | 3768 (97.8) | 1 |
| <20 | 12 (0.8) | 42 (1.1) | 0.73 (0.37–1.46) |
| ≥20 | 15 (1.0) | 41 (1.1) | 1.16 (0.61–2.20) |
| Missing | 2 (0.1) | 2 (0.1) | |
| χ2 trend; P-value | 0.00; 0.98 | ||
| Cigarette and cigar and pipe | 178 (3.0) | 276 (2.5) | 1.71 (1.36–2.13) |
| Cigarette and cigar | 183 (3.1) | 339 (3.1) | 1.32 (1.07–1.63) |
| Cigarette and pipe | 206 (3.5) | 390 (3.5) | 1.43 (1.16–1.75) |
| Cigar and pipe | 47 (0.8) | 98 (0.9) | 1.13 (0.76–1.69) |
| Grams of tobacco/dayc | |||
| Never tobacco smokers | 1255 (98.2) | 3570 (97.7) | 1 |
| <20 | 10 (0.8) | 53 (1.5) | 0.64 (0.31–1.31) |
| ≥20 | 13 (1.0) | 29 (0.8) | 1.42 (0.70–2.85) |
| Missing | – | 2 (0.1) | |
| χ2 trend; P-value | 0.07; 0.80 | ||
a
Smokeless tobacco users were excluded (130 cases and 267 controls).
b
Estimates from multiple logistic regression models, adjusted for center, race, sex, age, education, history of diabetes, body mass index and total alcohol consumption.
c
No information was available in the LSU (unpublished data), Toronto [19], Mayo Clinic [18] and MSKCC [17] studies.
CI, confidence interval; MSKCC, Memorial Sloan-Kettering Cancer Center; OR, odds ratios.