Table 2.

Cox Univariate and Multivariate Analyses of RFS of Chk1, Chk2, and MCM3 According to mRNA Expression (Cohort 1) and Protein Expression (Cohort 2).

Cohort 1 (mRNA)			Cohort 2 (Protein)
	HR (95% CI)	P		HR (95% CI)	P
MCM3			MCM3
Univariate			Univariate
Low	1.00		Low	1.00
High	1.98 (1.18–3.31)	.01	High	1.82 (1.09–3.04)	.022
Multivariate			Multivariate
Low	1.00		Low	1.00
High	2.39 (1.30-0.72)	.383	High	1.05 (0.60–1.83)	.871
Chk1			Chk1
Univariate			Univariate
Low	1.00		Low	1.00
High	2.05 (1.33–3.15)	.001	High	1.70 (1.08–2.68)	.023
Multivariate			Multivariate
Low	1.00		Low	1.00
High	1.37 (0.84–2.24)	.203	High	1.22 (0.71–2.10	.47
Chk2			Chk2
Univariate			Univariate
Low	1.00		Low	1.00
High	1.61 (1.19–2.19)	.002	High	1.59 (1.03–2.46)	.036
Multivariate			Multivariate
Low	1.00		Low	1.00
High	1.52 (1.08–2.13)	.015	High	1.21 (0.74–1.97)	.448

Multivariate analysis included adjustment for age (continuous), stage (I–II vs III–IV), grade (1–2 vs 3), and residual disease (none vs any, only available for cohort 1).