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(A) CVX-045 (-■-) inhibits the serum-induced migration of endothelial cells. CVX-045 (-▴-) in the absence of FBS had no effect on endothelial cell migration. Values are mean ± SEM, n = 4. (B) CVX-045 significantly (P < .05, ANOVA, Dunnett post test, n = 3 per group) inhibits FGF-2.induced angiogenesis at doses of 0.1 to 1 mg/kg as determined by quantifying CD31 staining in a Matrigel plug assay.
