Figure 4.

Hippocampal adenosine A₁R inactivation prevents LTP deficits produced by SD. A, Input/output curves relating presynaptic fiber volley amplitude to the initial slope of the resulting fEPSP are not different across groups. B, Paired-pulse facilitation is unaffected across groups at any of the intervals examined. C, L-LTP was induced as in Figure 1. SD mice treated with vehicle showed a L-LTP impairment in CA1 compared with the undisturbed controls (NSD). D, The L-LTP impairment is prevented in SD mice treated with a chronic infusion of the adenosine A₁R antagonist CPT. CPT treatment alone does not affect the maintenance of LTP (CPT-NSD vs VEH-NSD). Insets show representative recordings from an animal from each group taken during the first and last 5 min of the recording. Values are means ± SEM and n represents the number of animals.