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. Author manuscript; available in PMC: 2011 Jul 20.
Published in final edited form as: Nat Biotechnol. 2010 Nov 21;28(12):1279–1285. doi: 10.1038/nbt.1711

Figure 4. Metabolically affected brain regions in AD show significant suppression of central metabolic pathways.

Figure 4

In certain AD brain regions, the metabolic rate of glucose decreases more than can be explained by brain atrophy. PathWave analysis demonstrates that histopathogically normal cells from the metabolically affected brain regions (EC, HIP, MTG, and PC) demonstrate a significant suppression of central metabolic pathways, such as (a) glycolysis and (b) the TCA cycle and surrounding reactions. Metabolically less affected regions (SFG and VCX) show no significant suppression. Reaction suppression shown here is a composite expression of the reaction associated genes and the genes of closely connected reactions. Only significantly changed reactions are shown (FDR = 0.05). EC = entorhinal cortex, HIP = hippocampus, MTG = middle temporal gyrus, PC = posterior cingulate cortex, SFG = superior frontal gyrus, VCX = visual cortex. All reaction and metabolite abbreviations are defined in Supplementary Tables 1– 2.