Table 1.
| Auto-inflammatory Diseases |
| Dominant Cytokine = IL-1β; secondary cytokine = IL-6 Dominant Cell = Macrophage > T-cell> B-cell |
| Examplesa |
| Familial Mediterranean Fever |
| Familial Cold Auto-inflammatory Syndrome |
| Muckle-Wells Syndrome |
| Neonatal Onset Multi-inflammatory Disease |
| Hyper IgD Syndrome |
| Adult and juvenile Still’s Disease |
| Anti-Synthetase Syndrome |
| Macrophage Activation Syndrome |
| Urticarial vasculitis |
| Behçet’s’s Syndrome; Blau’s Syndrome; PAPA Syndrome |
| Schnitzler’s Syndrome; Sweet’s Syndrome |
| Urate Crystal Arthritis (Gout) |
| Type 2 Diabetes |
| Auto-immune Diseases |
| Dominant Cytokine = TNFα; secondary cytokines = IFNγ/IL-17/ Dominant Cell = T-cell > Macrophage; secondary cell = B-cell |
| Examples a |
| Rheumatoid arthritis |
| Juvenile rheumatoid arthritis |
| Ankylosing spondylitis |
| Crohn’s disease |
| Psoriasis |
| Lupus erythematosus |
| Pemphygus |
| Wegener’s granulomatosis |
| Sarcoidosis |
a
Blocking IL-1β effective therapy; blocking IL-6 effective; blocking TNFα minimally effective or exacerbation of disease
a
Blocking TNFα, IL-23, CD20, CTLA-1 Ig, IL-1β effective therapy