Table I.
Distribution of clinicopathological features including Wnt antagonist methylation in primary colorectal carcinomas from Ontario and Newfoundland
| No. of cases (%) |
||
| Ontario | Newfoundland | |
| Cases of primary colorectal carcinoma | 549 | 696 |
| Mean age (±SD) | 60.6 ± 8.8 | 61.3 ± 9.4 |
| White ethnicity | 549 (100) | 696 (100) |
| Age | ||
| <50 | 62 (11.1) | 83 (11.9) |
| 50+ | 487 (88.9) | 613 (88.1) |
| Sex | ||
| Female | 263 (47.9) | 268 (38.5) |
| Male | 286 (52.1) | 428 (61.5) |
| Tumor locationa | ||
| Proximal | 209 (38.1) | 289 (41.5) |
| Distal | 332 (60.5) | 397 (57.0) |
| Unavailable/overlapping | 8 (1.5) | 10 (1.4) |
| TNM stage | ||
| 1 | 96 (17.5) | 102 (14.7) |
| 2 | 211 (38.4) | 237 (34.1) |
| 3 | 168 (30.6) | 211 (30.3) |
| 4 | 30 (5.5) | 145 (20.8) |
| Unavailable | 44 (8.0) | 1 (0.1) |
| Histological grade | ||
| Low | 43 (7.8) | 101 (14.5) |
| Moderate | 392 (71.4) | 511 (73.4) |
| High | 64 (11.7) | 71 (10.2) |
| Unavailable | 50 (9.1) | 13 (1.9) |
| Histological typeb | ||
| Non-mucinous | 446 (81.2) | 610 (87.6) |
| Mucinous | 64 (11.7) | 86 (12.4) |
| Unavailable | 39 (7.1) | 0 (0.0) |
| MSI status | ||
| Stable | 385 (70.1) | 593 (85.2) |
| Low | 71 (12.9) | 28 (4.0) |
| High | 88 (16.0) | 68 (9.8) |
| Unavailable | 5 (0.9) | 7 (1.0) |
| MMR germ line mutation | ||
| No | 181 (33.0) | 679 (97.6) |
| Yes | 15 (2.7) | 17 (2.4) |
| Unavailable | 353 (64.3) | 0 (0.0) |
| MMR protein status | ||
| Intact | 448 (81.6) | 614 (88.2) |
| Deficient | 76 (13.8) | 61 (8.8) |
| Unavailable | 25 (4.6) | 32 (3.0) |
| MLH1 methylation | ||
| No | 496 (90.5) | 418 (60.1) |
| Yes | 52 (9.5) | 19 (2.7) |
| Unavailable | 0 0.0) | 259 (37.2) |
| BRAF V600E mutation | ||
| No | 467 (85.1) | 576 (82.8) |
| Yes | 63 (11.5) | 77 (11.1) |
| Unavailable | 19 (3.5) | 43 (6.2) |
| DKK1 methylation | ||
| Unmethylated | 477 (87.0) | 602 (86.5) |
| Methylated | 71 (13.0) | 94 (13.5) |
| SFRP1 methylation | ||
| Unmethylated | 28 (5.1) | 41 (5.9) |
| Low | 380 (69.2) | 481 (69.1) |
| High | 141 (25.7) | 174 (25.0) |
a
Proximal tumor location includes lesions up to and including the splenic flexure.
b
Mucinous histology includes presence of any mucin within the tumor stroma.