Table IV.

Multivariate MSI analysis adjusted for age, sex, tumor location and DKK1 or SFRP1 methylation in Ontario and Newfoundland

Variable	Ontario			Newfoundland
	Univariate, P	Multivariate, P	Multivariate OR (95% CI)	Univariate, P	Multivariate, P	Multivariate OR (95% CI)
Age	0.94	0.11	1.0 (0.9–1.0)	0.06	0.003	1.0 (0.9–1.0)
Female sex	3.46 × 10−3	0.71	1.1 (0.6–2.0)	0.05	0.57	1.2 (0.7–2.1)
Proximal location	4.37 × 10−15	5.54 × 10−11	7.7 (4.3–14.2)	1.31 × 10−12	1.65 × 10−6	5.3 (2.6–10.0)
DKK1 methylation	5.46 × 10−20	1.26 × 10−12	10.7 (5.6–20.7)	3.87 × 10−15	1.19 × 10−9	6.3 (3.5–11.4)
Variable	Ontario			Newfoundland
	Univariate, P	Multivariate, P	Multivariate OR (95% CI)	Univariate, P	Multivariate, P	Multivariate OR (95% CI)
Age	0.94	0.86	1.0 (1.0–1.0)	0.06	0.02	1.0 (0.9–1.0)
Female sex	0.003	0.08	1.6 (1.0–2.7)	0.05	0.22	1.4 (0.8–2.4)
Proximal location	4.37 × 10−15	9.45 × 10−14	9.1 (1.7–5.3)	1.31 × 10−12	2.05 × 10−9	7.1 (3.8–14.3)
SFRP1 methylation	1.33 × 10−4	0.009	n/a	0.009	0.14	n/a
Low	n/a	0.34	1.2 (0.4–3.5)	n/a	0.64	0.8 (0.3–2.0)
High	n/a	0.47	0.3 (0.1–1.2)	n/a	0.09	0.4 (0.1–1.2)

n/a, not applicable; β-cat, β-catenin; JNK, c-Jun N-terminal kinase; CamKII, Calmodulin-dependent protein kinase II.