Table 2.
Univariate associations of laboratory markers of infection with the development of an infection and serious infection during the hospital stay.
| No infection N = 55 | Infection N = 39 | P | Serious infection N = 19 | P* | Normal Range | |
|---|---|---|---|---|---|---|
| Markers of Infection | ||||||
| Mean temperature day 1 (°C) | 36.7 ± 0.1 | 37.4 ± 0.1 | <.0001 | 37.4 ± 0.2 | .001 | |
| Mean temperature day 3 (°C) | 36.9 ± 0.1 | 37.7 ± 0.1 | <.0001 | 37.9 ± 0.1 | <.0001 | |
| Procalcitonin day 1 (ng/mL) | 0.05 ± 0.01 | 0.29 ± 0.23 | NS | 0.53 ± 0.01 | NS | <0.5 |
| Procalcitonin day 3 (ng/mL) | 0.05 ± 0.01 | 0.34 ± 0.24 | NS | 0.63 ± 0.49 | .04 | <0.5 |
| Procalcitonin day 5 (ng/mL) | 0.05 ± 0.01 | 0.20 ± 0.05 | .002 | 0.35 ± 0.10 | <.0001 | <0.5 |
| Interleukin-6 day 1 (pg/mL) | 7.35 ± 1.8 | 17.0 ± 4.15 | .019 | 21.6 ± 7.5 | .009 | <6.0 |
| Interleukin-6 day 3 (pg/mL) | 9.0 ± 1.5 | 24.2 ± 4.0 | <.0001 | 36.25 ± 6.8 | <.0001 | <6.0 |
| Interleukin-6 day 5 (pg/mL) | 9.0 ± 1.55 | 37.4 ± 11.3 | .004 | 64.6 ± 21.5 | <.0001 | <6.0 |
| Lipopolysaccaride-binding protein day 1 (mcg/mL) | 19.0 ± 1.6 | 26.6 ± 2.8 | .014 | 29.3 ± 4.5 | .008 | <8.4 |
| Lipopolysaccaride-binding protein day 3 (mcg/mL) | 25.0 ± 2.1 | 44.7 ± 6.1 | .001 | 54.3 ± 10.9 | <.0001 | <8.4 |
| Lipopolysaccaride-binding protein day 5 (mcg/mL) | 23.4 ± 2.1 | 50.9 ± 6.0 | <.0001 | 66.5 ± 10.9 | <.0001 | <8.4 |
| C-reactive protein day 1 (mg/L) | 10.2 ± 2.0 | 19.2 ± 5.2 | NS | 22.8 ± 7.1 | .022 | 0–5.0 |
| C-reactive protein day 3 (mg/L) | 12.2 ± 2.1 | 46.7 ± 9.45 | <.0001 | 58.3 ± 10.2 | <.0001 | 0–5.0 |
| C-reactive protein day 5 (mg/L) | 10.0 ± 1.4 | 78.9 ± 14.0 | <.0001 | 113.7 ± 24.9 | <.0001 | 0–5.0 |
| White blood cells day 1 (Gpt/L) | 8.35 ± 0.4 | 10.3 ± 0.5 | .006 | 11.7 ± 0.8 | <.0001 | 4.0–11.0 |
| White blood cells day 3 (Gpt/L) | 8.3 ± 0.8 | 11.9 ± 1.7 | .034 | 11.3 ± 0.8 | .034 | 4.0–11.0 |
| White blood cells day 5 (Gpt/L) | 7.4 ± 0.6 | 9.6 ± 0.5 | .01 | 10.7 ± 0.8 | .006 | 4.0–11.0 |
| Monozyte HLA-DR expression day 1 (%) | 96.0 ± 0.7 | 92.9 ± 1.5 | .039 | 92.1 ± 2.4 | .034 | >30 |
| Monozyte HLA-DR expression day 3 (%) | 95.1 ± 1.2 | 88.1 ± 2.1 | .002 | 89.1 ± 2.0 | .011 | >30 |
| Monozyte HLA-DR expression day 5 (%) | 94.2 ± 1.3 | 88.5 ± 2.0 | .014 | 85.6 ± 3.1 | .004 | >30 |
Data are shown as number for dichotomized variables mean ± standard error of the mean (SEM) for normally distributed continuous variables, or median (range) for abnormally distributed continuous variables. *P value for analysis of serious infection versus no infection.