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. Author manuscript; available in PMC: 2011 Jul 20.
Published in final edited form as: Arch Neurol. 2010 May;67(5):536–541. doi: 10.1001/archneurol.2010.88

Figure 2.

Figure 2

Phylogenetic tree constructed for the region of interest in TOMM40. Figure 2 (left panel) illustrates the first major branch point in this tree, at rs8106922 (922). The ovals capture subsequent branch points (mutation events). Frequencies of APOE genotypes in clades A and B are indicated. The dotted line highlights the separation between the two major clades. The boxes in figure 2 (right panel) indicate the clades that are differentiated by length of the poly-T allele (523). APOE3 can be linked to long or short 523 poly-T alleles (black boxes). APOE4 is connected to long poly-T alleles (red boxes).