Skip to main content
. Author manuscript; available in PMC: 2011 Jul 20.
Published in final edited form as: Vasc Med. 2009 Aug;14(3):249–257. doi: 10.1177/1358863X08100040

Figure 4.

Figure 4

Vascular reactivity studies represented by concentration-effect curves of rings of aortae from 12 week old mice. a) endothelium-independent vasorelaxation in response to NTG of segments of aorta from E+ (n = 6, open circles), E+chol (n = 6, open diamonds), E− (n = 6, filled circles) and E−chol (n = 9, solid diamonds). The E− curve demonstrates significant attenuation of vasorelaxation at the middle three doses. This effect was not observed in the other two high cholesterol groups. b) Concentration-effect curves demonstrating endothelium-dependent vasorelaxation in response to ACh. The curves of the three high cholesterol groups demonstrate significant attenuation of relaxation by MANOVA. * P < 0.05 vs. E+ at the same dose.