Table 2.
Human CD14 Single-Nucleotide Polymorphisms (SNPs) Studied and Their Association With Traveler’s Diarrhea (TD) Among White Visitors to Mexico
| No. (%) of subjects |
|||||
| SNP, genotype | All subjects | Healthy subjects | Subjects with TD | Pa | HWE Pb |
| CD14 01 (C>T) (n = 762) | |||||
| CC | 394 (51.7) | 207 (53.9) | 187 (49.5) | ||
| CT | 295 (38.7) | 145 (37.8) | 150 (39.9) | ||
| TT | 73 (9.6) | 32 (8.3) | 41 (10.8) | .34 | .36 |
| CD14 EX02 (C>G) (n = 961) | |||||
| CC | 772 (80.3) | 397 (82.2) | 375 (78.5) | ||
| CG | 185 (19.3) | 84 (17.4) | 101 (21.1) | ||
| GG | 4 (0.42) | 2 (0.41) | 2 (0.42) | .34 | 0.27 |
| CD14 -159 (C>T) (n = 959) | |||||
| CC | 247 (25.8) | 134 (27.0) | 113 (24.4) | ||
| CT | 440 (45.9) | 240 (48.4) | 200 (43.2) | ||
| TT | 272 (28.4) | 122 (24.6) | 150 (32.4) | .02 | .48 |
| CD14 -1145 (A>G) (n = 897) | |||||
| AA | 264 (29.4) | 142 (31.5) | 122 (27.7) | ||
| AG | 424 (47.3) | 221 (48.5) | 203 (46.0) | ||
| GG | 209 (23.3) | 93 (20.4) | 116 (26.3) | .10 | .68 |
| CD14 -2839 (G>A) (n = 772) | |||||
| GG | 427 (55.3) | 220 (56.1) | 207 (54.5) | ||
| GA | 290 (37.6) | 148 (37.8) | 142 (37.4) | ||
| AA | 55 (7.1) | 24 (6.1) | 31 (8.2) | .54 | .89 |
| CD14 -4191 (C>T) (n = 897) | |||||
| CC | 538 (59.9) | 255 (55.6) | 283 (64.6) | ||
| CT | 310 (34.6) | 170 (37.0) | 140 (31.9) | ||
| TT | 49 (5.5) | 34 (7.4) | 15 (3.4) | .003 | .44 |
a
Healthy subjects versus subjects with TD.
b
HWE, Hardy-Weinberg equilibrium P value estimated for healthy control population.