Table 4.
Distribution and Association of CD14 -159 C > T and -4191 C > T Single Nucleotide Polymorphism (SNP) Genotypes and Alleles With the Identification of Enteric Pathogens
| Variable | Enteropathogen identified, no. of positive specimens/no. of stool specimens tested |
||||||
| Healthy subjects | Bacterial pathogen | EAEC | ETEC | EPEC | STEC | EIEC | |
| CD14-159 C > T (n = 959) | n = 496 | n = 178/294 | n = 110/292 | n = 117/289 | n = 70/163 | n = 18/162 | n = 14/163 |
| Genotype | |||||||
| C/C n =247 | 134 (27.0) | 34 (19.1) | 20 (18.2) | 22 (18.8) | 15 (21.4) | 3 (16.7) | 6 (42.6) |
| C/T n =440 | 240 (48.4) | 83 (46.6) | 48 (43.6) | 55 (47.0) | 33 (47.1) | 8 (44.4) | 4 (28.6) |
| T/T n =272 | 122 (24.6) | 61 (34.3) | 42 (38.2) | 40 (34.2) | 22 (31.4) | 7 (38.9) | 4 (28.6) |
| P | .01a | .009a | .05a | .39a | .38a | .29a | |
| TT status | |||||||
| Non-TT (n =687) | 374 (75.4) | 117 (65.7) | 68 (61.8) | 77 (65.8) | 48 (68.6) | 12 (63.2) | 10 (71.4) |
| TT (n =272) | 122 (24.6) | 61 (34.3) | 42 (38.2) | 40 (34.2) | 22 (31.4) | 7 (36.8) | 4 (28.6) |
| RR (95% CI) | 1.40 (1.0–1.80) | 1.66 (1.18–3.32) | 1.45 (1.03–2.01) | 1.34 (0.86–2.12) | 1.74 (0.72–4.21) | 1.30 (0.41–3.60) | |
| P | .01b | .006b | .03b | .24b | .27b | .75b | |
| Allele | |||||||
| C (n =1008) | 508 (51.2) | 151 (42.4) | 88 (40.0) | 99 (42.3) | 63 (45.0) | 14 (38.9) | 16 (57.1) |
| T (n =910) | 484 (48.8) | 205 (57.6) | 132 (60.0) | 135 (57.7) | 77 (55.0) | 22 (61.1) | 12 (42.9) |
| RR (95% CI) | 1.3 (1.08–1.56) | 1.45 (1.14–1.85) | 1.34 (1.06–1.70) | 1.24 (0.91–1.70) | 1.62 (0.85–3.10) | 0.79 (0.38–1.63) | |
| P | .004b | .003b | .01b | .17b | .17b | .57b | |
| CD14-4191 C > T (n = 897) | n = 459 | n = 166/294 | n = 93/291 | n = 92/291 | n = 60/135 | n = 15/134 | n = 13/135 |
| Genotype | |||||||
| CC (n =538) | 255 (55.6) | 111 (66.9) | 68 (73.1) | 63 (68.5) | 43 (71.7) | 8 (53.3) | 7 (53.8) |
| CT (n =310) | 170 (37.0) | 50 (30.1) | 22 (23.7) | 28 (30.4) | 14 (23.3) | 6 (40.0) | 4 (30.8) |
| TT (n =49) | 34 (7.4) | 5 (3.0) | 3 (3.2) | 1 (1.1) | 3 (5.0) | 1 (6.7) | 2 (15.4) |
| P | .01a | .006a | .01a | .07a | .97a | .54a | |
| CC status | |||||||
| CC (n =538) | 255 (55.6) | 111 (66.9) | 68 (73.1) | 63 (68.5) | 43 (71.7) | 8 (53.3) | 7 (53.8) |
| Non-CC (n =359) | 204 (44.4) | 55 (33.1) | 25 (26.9) | 29 (31.5) | 17 (28.3) | 7 (46.7) | 6 (46.2) |
| RR (95% CI) | 0.70 (0.5–0.98) | 0.52 (0.34–0.79) | 0.63 (0.42–0.94) | 0.53 (0.31–0.90) | 1.09 (0.40–2.95) | 1.06 (0.36–3.13) | |
| P | .01b | .002b | .03b | .02b | 1b | 1b | |
| Allele | |||||||
| C (n =1386) | 680 (74.1) | 272 (81.9) | 158 (84.9) | 154 (83.7) | 100 (83.3) | 22 (73.3) | 18 (69.2) |
| T (n =408) | 238 (25.9) | 60 (18.1) | 28 (15.1) | 30 (16.3) | 20 (16.7) | 8 (26.7) | 8 (30.8) |
| RR (95% CI) | 0.70 (0.55–0.90) | 0.56 (0.38–0.81) | 0.61 (0.42–0.84) | 0.64 (0.38–0.96) | 1.04 (0.47–2.30) | 1.26 (0.36–2.86) | |
| P | .004b | .001b | .005b | .03b | .92b | .6b | |
NOTE. CI, confidence interval; EAEC, Enteroaggregative Escherichia coli; EIEC, Enteroinvasive E. coli; EPEC, Enteropathogenic E. coli; ETEC, Enterotoxigenic E. coli (producing ST, LT, or LT/ST); RR, relative risk; STEC, Shiga toxin–producing E. coli.
a
3 × 2 χ2 test, for comparing with enteropathogens versus healthy control subjects.
b
2 × 2 χ2 test, for comparing with enteropathogens versus healthy control subjects.