Table 1.
Summary of coregistration of gene expression and cortical areas
| Motor Cx (m) | Somato Cx (s) | Visual Cx (v) | Auditory Cx (a) | |
| E13.5 (3/7 GE) | r: None | NA | c: | NA |
| COUP-TFI−* | ||||
| Id2− | ||||
| Lhx2+* | ||||
| E14.5 (4/7 GE) | r: | NA | c: | NA |
| COUPTFI−* | COUPTFI−* | |||
| Id2+ | Id2+ | |||
| Lhx2− | Lhx2+* | |||
| Cad8+* | Cad8−* | |||
| E16.5 (6/7 GE) | COUPTFI−* | COUPTFI−* | COUPTFI+ | COUPTFI+* |
| Id2+* | Id2+* | Id2+ | Id2+* | |
| Lhx2− | Lhx2− | Lhx2+* | Lhx2+* | |
| RZRß+ | RZRß+ | RZRß− | RZRß+ | |
| Cad8+ | Cad8+ | Cad8−* | Cad8+* | |
| EphA7+ | EphA7+ | EphA7−* | EphA7+* | |
| E18.5 (7/7 GE) | COUPTFI−* | COUPTFI−* | COUPTFI+ | COUPTFI+ |
| Id2+* | Id2+ | Id2+ | Id2+* | |
| Lhx2−* | Lhx2+ | Lhx2+ | Lhx2+* | |
| RZRß+ | RZRß+ | RZRß− | RZRß+ | |
| Cad8+* | Cad8+* | Cad8+* | Cad8−* | |
| EphA7+* | EphA7+* | EphA7− | EphA7+* | |
| EphrinA5− | EphrinA5+ | EphrinA5−* | EphrinA5−* | |
| P0 (7/7 GE) | COUPTFI+ | COUPTFI+ | COUPTFI+ | COUPTFI+ |
| Id2+ | Id2+ | Id2+ | Id2+* | |
| Lhx2+ | Lhx2+ | Lhx2+ | Lhx2+* | |
| RZRß+ | RZRß+ | RZRß+ | RZRß+ | |
| Cad8+* | Cad8+* | Cad8+ | Cad8−* | |
| EphA7+* | EphA7−* | EphA7+ | EphA7−* | |
| EphrinA5−* | EphrinA5+* | EphrinA5+ | EphrinA5+* | |
| P3 (7/7 GE) | COUPTFI+ | COUPTFI+ | COUPTFI+ | COUPTFI+* |
| Id2+* | Id2+ | Id2+ | Id2+ | |
| Lhx2+ | Lhx2+ | Lhx2+ | Lhx2+ | |
| RZRß+ | RZRß+ | RZRß+ | RZRß+* | |
| Cad8+* | Cad8+* | Cad8+ | Cad8−* | |
| EphA7+* | EphA7+ | EphA7+ | EphA7−* | |
| EphrinA5−* | EphrinA5+* | EphrinA5+ | EphrinA5+ |
Note: Cx, cortex; GE, genes expressed; r, early rostral area; NA, cortical area not defined at this age; c, early caudal area; m, putative motor area; s, putative somatosensory area; v, putative visual area; a, putative auditory area. A summary of the coregistration of information for gene expression of COUP-TFI, Id2, Lhx2, Cad8, EphA7, EphrinA5, and RZRß and arealization as gauged by INCs. Far left column 1: age (E13.5–P3) and number of genes under study expressed at that age (n/7). Columns 2–5: coregistration data for putative motor, somatosensory, visual, and auditory cortex, respectively. Within each box: all 7 genes are noted with “+” or “−” to indicate if the area in question is found to be overlapping (+) or nonoverlapping (−) with gene expression and “*” denotes whether a gene expression boundary is adjacent to or abuts a cortical area boundary. Gene expression/areal boundary coregistration differs for the 4 regions: caudal visual boundary coregistration occurs mostly at earlier ages (E.13.5–18.5), caudolateral auditory boundary coregistration occurs later (E16.5–P0), and motor/somatosensory area boundary coregistration occurs (E18.5–P3), indicating a role of gene expression in the caudal to rostral development of the cortex.