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. Author manuscript; available in PMC: 2011 Jul 20.
Published in final edited form as: Immunity. 2008 Nov 14;29(5):758–770. doi: 10.1016/j.immuni.2008.09.018

Fig. 7. RARα signaling can indirectly alter Foxp3 conversion in vivo.

Fig. 7

A) Foxp3− OT-II RAG-1−/− CD45.1 CD4+ T cells were sorted then injected IV into RARα KO mice or WT littermates (0.5–1 × 106 cells/mouse). Mice were given water supplemented with ovalbumin (1.5%) for 7 days after which point they were sacrificed and donor OT-II CD45.1 T cells from various lymphoid organs were analyzed for Foxp3 expression by FACS. Representative FACS plots showing Foxp3 expression in CD45.1+ CD4+ T cells from the mesenteric lymph nodes of either a WT or RARα KO host. B) Summary of Foxp3 expression in donor CD45.1+ OT-II T cells harvested from lamina propria or mesenteric lymph nodes of RARα KO mice or WT littermate controls from multiple experiments.