Fig. 4. Three-dimensional distribution of residues with Rex (red) in dsRBM1 and dsRBM2. The side-chains of the dsRNA binding residues from regions 1–3 are displayed. The residues with Rex or exchange broadening are displayed in green; the residues without Rex are displayed in magenta; and the residues unanalyzed due to spectral overlap are displayed in pink. Notice that regions surrounding the RNA binding site of dsRBM1 are covered by residues with Rex. A network of interactions extends the exchange effects from the dsRNA binding site to the surrounding regions such as the central hydrophobic core involving residues from α1, β1, β2 and α2.