Figure 8.

Immunohistochemical expresssion of MCM2 protein in HNB tissues with low-grade and high-grade molecular abnormalities and in IDCs. There is an obvious trend toward increasing expression from HNB tissues with low-grade molecular abnormality (white bars) to those with high-grade molecular abnormality (gray bars), and the IDCs (black bars), thus providing evidence for cross-platform validation of our original expression profiling data for MCM2 at the protein level. (a) Is the specimen-wise distribution of immunohistochemical expression of MCM2 for the HNB tissues with low-grade and high-grade molecular abnormality and IDC groups. (b) Is the pairwise comparison of MCM2 immunostaining among the three groups. The adjusted P value for each comparison, based on Tukey method, is shown on (b).