Table 1.
Clinicopathologic summary of IDC, molecularly high-risk and molecularly low-risk, histologically normal breast tissue specimens.
| Outside institution | Moffitt Cancer Center (MCC) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case no. | Tiisue core ID (frozen specimens for microarray) | Patient age (Years) | Side of breast sampled | Date of first-tissue diagnosis of BRCA | Surgical procedure at first-tissue diagnosis of BRCA; INA = Information not available | Pathologic diagnosis of BRCA | Date of surgical procedure at MCC | Side of breast sampled | Surgical procedure | Axillary LN dissection = AX; Sentinel LN dissection, axillary = SLN-AX; Not done = ND | Final pathologic diagnosis | Histologic grade (Invasive carcinoma) | Tumor size (cm) | DCIS | Other histopathologic findings (resected specimen) |
| 1 | X | 41 | Left | 2001.04.10 | Core biopsy | IDC, DCIS, high grade, comedo type | 2005.08.04 | Left | Lumpectomy | Intramammary lymph nodes | IDC | 3 | 5 | Present | X |
| 1 | X | 41 | Right | X | X | X | 2005.08.04 | Right | Lumpectomy | ND | IDC | 3 | 4 | Present | Skeletal muscle invasion, multifocal |
| 2 | X | 38 | Left | 2005.07.01 | Core biopsy | IDC | 2005.08.03 | Left | Modified radical mastectomy | SLN-AX | Papillary CA with a focus of IDC | 3 | 7.5 | Present | IDC focus 0.8 cm |
| 3 | X | 68 | Right | 2005.07.20 | INA | IDC | 2005.08.09 | Right | Total mastectomy | SLN-AX | IDC | 3 | 2.2 | Present | X |
| 4 | X | 47 | Left | 2005.11.28 | INA | IDC | 2006.01.09 | Left | Mastectomy | SLN-AX | IDC | 3 | 2 | Present | Focal ductal hyperplasia, radial scar, sclerosing adenosis, microcalcifications |
| 4 | X | 47 | Right | X | X | X | 2006.01.09 | Right | Mastectomy | SLN-AX | Fibroadenomatoid hyperplasia, florid ductal hyperplasia, sclerosing adenosis, microcalcifications | NA | NA | Absent | X |
| 5 | X | 53 | Right | 2006.05.09 | Core biopsy | IDC | 2006.07.31 | Right | Mastectomy | AX | Residual IDC | 3 | 2.8 | NS | involve dermis of skin/nipple |
| 6 | X | 71 | Left | 2006.04.12 | Core biopsy | Ductal & Lobular CA | 2006.05.23 | Left | Modified radical mastectomy | SLN-AX | IDC w/lobular features | 3 | 4 | Present | Tumor involves dermal angiolymphatic space in areola |
| 7 | 1480 | 61 | Right | 2006.05.09 | INA | IDC | 2006.08.01 | Right | Mastectomy | SLN-AX | Benign breast | NA | NA | Absent | ALH, proliferative fibrocystic changes |
| 7 | X | 61 | Left | X | X | X | 2006.08.01 | Left | Mastectomy | SLN-AX | IDC | 2 | 2.6 | Absent | |
| 8 | 1481 | 86 | Right | 2006.07.31 | Core biopsy | IDC | 2006.08.29 | Right | Total mastectomy | SLN-AX | IDC | 3 | 8.5 | Present | involve dermis of skin/nipple |
| 9 | 1482 | 52 | Left | 2006.02.22 | Core biopsy | IDC | 2006.03.30 | Left | Total mastectomy, skin-sparing | SLN-AX | IDC | 2 | 1.5 | Present | X |
| 10 | 1483 | 80 | Left | 2005.06.13 | Excisional biopsy | Mucinous Carcinoma | 2005.08.16 | Left | Total mastectomy | Not done | No residual carcinoma | NA | NA | Absent | X |
| 11 | 1484 | 42 | Left | 2005.07.06 | Core biopsy | DCIS solid type | 2005.08.15 | Left | Mastectomy | SLN-AX | Residual DCIS | NA | 0.4 | Present | DCIS, multifocal |
| 11 | X | 42 | Right | X | X | X | 2005.08.15 | Right | Mastectomy | SLN-AX | Benign breast | NA | NA | Absent | X |
| 12 | 1485 | 52 | Left | 2006.03.31 | Core biopsy | IDC | 2006.05.30 | Left | Total mastectomy | ND | No residual carcinoma | NA | NA | Absent | X |
| 12 | X | 52 | Right | X | X | X | 2006.05.30 | Right | Rt modified radical prophylactic mastectomy | AX | Benign breast | NA | NA | Absent | X |
| 13 | 1486 | 67 | Right | 2006.05.02 | Core biopsy | DCIS | 2006.07.12 | Right | Mastectomy | SLN-AX | DCIS | NA | 1.2 | Present | X |
| 13 | X | 67 | Left | X | X | X | 2006.07.12 | Left | prophylactic mastectomy | SLN-AX | Benign breast | NA | NA | Absent | X |
| 14 | 1487 | 67 | Left | 2006.06.12 | Core biopsy | DCIS | 2006.07.31 | Left | Mastectomy | SLN-AX | No residual DCIS | NA | NA | Absent | |
| 14 | X | 67 | Right | X | X | X | 2006.07.31 | Right | prophylactic mastectomy | SLN-AX | Benign breast | NA | NA | Absent | microcalcifications |
| 15 | 1488 | 49 | Left | 2005.05.23 | Excisional biopsy | DCIS | 2005.08.02 | Left | Total Mastectomy | SLN-AX | Residual DCIS | NA | X | Present | X |
| 16 | 1489 | 49 | Left | 2005.05.27 | Excisional biopsy, subareolar | Adenoid cystic CA | 2005.06.14 | Left | Total Mastectomy | SLN-AX | No residual carcinoma | NA | NA | Absent | ADH |
| 16 | X | 49 | Right | X | X | X | 2005.06.14 | Right | prophylactic mastectomy | SLN-AX | Benign breast | NA | NA | Absent | X |
| 17 | 1490 | 39 | Right | 2005.04.26 | Excisional biopsy | DCIS solid type | 2005.06.29 | Right | Mastectomy | SLN-AX | DCIS, multifocal | NA | 2.2 | Present | X |
| 18 | 1491 | 85 | Left | 2005.06.30 | Excisional biopsy | Intracystic CA | 2005.07.28 | Left | Mastectomy | SLN-AX | No residual carcinoma | NA | NA | Absent | ADH |
| 19 | 1492 | 47 | Left | 2005.11.11 | Needle-loc excisional biopsy | IDC | 2006.05.02 | Left | Skin-sparing total mastectomy | SLN-AX | IDC focal micropapillary features | 3 | 2.5 | Present | X |
| 19 | X | 47 | Right | 2006.02.27 | Needle core biopsy | Fibrocystic changes | 2006.05.02 | Right | Needle-loc excisional biopsy | SLN-AX | Adenoma w/adenomyoepitheliomatous features and focal atypia | NA | NA | Absent | Sclerosing adenosis, cystic/apocrine changes |
| 20 | 1493 | 55 | Right | 2006.01.03 | Cytology: Adenocarcinoma | IDC | 2006.02.20 | Right | Mastectomy | SLN-AX | IDC | 3 | 2 | NS | X |
| 20 | X | 55 | Left | X | X | X | 2006.02.20 | Left | Mastectomy | SLN-AX | ALH; No invasive carcinoma | NA | X | X | ALH involving lactiferous duct |
| 21 | 1494 | 50 | Right | 2006.03.15 | Core biopsy | IDC | 2006.05.22 | Right | Bilateral nipple sparing mastectomy | SLN-AX | No residual carcinoma | NA | NA | Absent | X |
| 21 | X | 50 | Left | X | X | X | 2006.05.22 | Left | As above | SLN-AX | Benign breast | NA | NA | Absent | X |
| 22 | 1495 | 18 | Right | NA | NA | No clinical evidence of invasive carcinoma | 2006.06.19 | Right | prophylactic mastectomy* | SLN-AX | Benign breast | NA | NA | Absent | X |
| 22 | X | 18 | Left | X | X | X | 2006.06.19 | Left | prophylactic mastectomy* | SLN-AX | Benign breast | NA | NA | Absent | X |
| 23 | 1496 | 56 | Right | 2006.04.04 | Unknown | DCIS | 2006.06.15 | Right | Bilateral mastectomy | SLN-AX | No residual DCIS | NA | NA | Absent | Ductal hyperplasia, microcalcifications |
| 23 | X | 56 | Left | X | X | X | 2006.06.15 | Left | Bilateral mastectomy | SLN-AX | Benign breast | NA | NA | Absent | Fat necrosis, microcalcifications |
| 24 | 1497 | 48 | Right | 2006.06.27 | Lumpectomy | IDC, ILC | 2006.07.28 | Right | Modified radical mastectomy | SLN-AX | No residual invasive carcinoma; LCIS involves nipple duct | NA | NA | Absent | X |
| 24 | X | 48 | Left | X | X | X | 2006.07.28 | Left | prophylactic mastectomy | ND | Benign breast | NA | NA | Absent | Focal secretory change |
*Strong family history of breast cancer and patient tested positive for BRCA1 gene.