Table 3.

Mean TOP2A and MCM2 indices and BUB1B protein expression scores in IDCs and molecularly high-risk and low-risk, histologically normal breast tissues.

Archival specimen type	Average no. of TDLUs evaluated/specimen (Range)	Mean TOP2A index (%) by IHC	Mean MCM2 index (%) by IHC	Mean BUB1B protein expression score (H-score) by IHC (Range)
IDCs (N = 6)	Not applicable	27 (15–35)	47 (30–80)	149 (80–200)
Histologically normal breast tissues with high-grade molecular abnormality (N = 9) on microarray	31 (6–39)	11 (2–30)	20 (8–35)	68 (33–113)
Histologically normal breast tissues with low-grade molecular abnormality (N = 9) on microarray	24 (17–35)	2 (1–3)	4 (1–12)	17 (10–22)
P value	.18	<.005	<.05	<.005