Table 1.
Ceftraroline’s Mean Inhibitory Concentrations (MICs) for Selected Organisms
| Organism | MIC90 (μg/ml) |
|---|---|
|
Gram-Positive Bacteria | |
| Staphylococcus aureus | |
| MSSA | 0.25 μg/ml (≤0.03–1.0) |
| MRSA | 0.5–2.0 |
| hVISA | 0.25–4.0 |
| Quinupristin-dalfopristin-resistant | 1 |
| Staphylococcus epidermidis | |
| Oxacillin-sensitive | 0.12 (0.06–0.12) |
| Oxacillin-resistant | 0.5 (0.25–2.0) |
| Vancomycin-intermediate (VISE) | ≤0.016–2.0 |
| Quinupristin-dalfopristin-resistant | 1.0 |
| Linezolid-resistant | 0.5 |
| Streptococcus pneumoniae | |
| Penicillin-susceptible | 0.015 |
| Penicillin-intermediate | 0.06 |
| Penicillin-resistant (MDRSP) | (0.12–0.25) |
| Ceftazidime-resistant | 1.0 |
| Ceftriaxone- and cefotaxime-resistant | 0.25 |
| Erythromycin-resistant | 0.25 |
| Levofloxacin-resistant | 0.12 |
| Streptococcus (β hemolytic) | <0.008–0.016 |
| Enterococcus faecalis | 2.0–4.0 |
| Enterococcus faecium | 16–64 |
| Gram-Negative Bacteria | |
| H. influenzae | <0.016–0.03 |
| Enterobacteriaceae | |
| No β-lactamases | 0.06–4.0 |
| ESBL positive | >32 |
| AmpC positive | >128 |
| Citrobacter freundii | 2.0 |
| E. coli | |
| All isolates | 0.12 |
| − TEM/SHV | 0.015–0.03 |
| +TEM/SHV | 0.5–2.0 |
| Klebsiella pneumoniae | 0.5 |
| Morganella morganii | 0.12 |
| Proteus mirabilis | 0.12 |
| Serratia marcescens | 2.0 |
| Non-Enterobacteriaceae | |
| Pseudomonas spp. | >32 |
| Acinetobacter spp. | 4–>128 |
| Stenotrophomonas maltophila | >32 |
| Anaerobes | |
| Peptostreptococcus spp. | 0.12 |
| Propionibacterium spp | 0.12 |
| Bacteroides spp. | >32 |
| Prevotella spp. | >32 |
| Pasteurella multocida | 0.06 |
| Clostridium difficile | 4 |