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The paper by Shields et al. shows that tumor cells use CCL21 induce a cascade of events that leads to tolerance, including stromal expression of TGFβ and alterations in the peripheral tumor stroma to one that is lymph-node-like. This results in conversion of naïve T cells to TRegs, and recruitment of MDSCs. Both TRegs and MDSCs contribute to the maintenance of self tolerance, reduced tumor surveillance, and enhanced tumor growth.
