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Kim et al. show that when circulating tumor cells (CTCs) re-seed the tumor, they express high levels of CXCL1, which recruits tumor promoting myeloid cells into the tumor and enhances angiogenesis. CTCs also exhibit enhanced expression of fascin and MMP1 which facilitate their invasive properties, resulting in greater infiltration into the tumor bed. Production of IL-6 and IL-8 by the tumor provides important attractants for recruitment of the CTCs into the tumor.
