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. Author manuscript; available in PMC: 2011 Jul 20.
Published in final edited form as: Annu Rev Anal Chem (Palo Alto Calif). 2009;2:265–277. doi: 10.1146/annurev.anchem.1.031207.112942

Figure 2.

Figure 2

Typical workflows for mass spectrometry–based biomarker discovery and validation. Abbreviations: FTMS, Fourier transform mass spectrometry; HPLC, high-performance liquid chromatography; ICAT, isotope-coded affinity tag; IMAC, immobilized metal affinity chromatography; ITRAQ, isotopic tag for relative and absolute quantification; LTQ, linear trap quadrupole; MS/MS, tandem mass spectrometry; RP, reverse-phase liquid chromatography; SCX, strong cation-exchange liquid chromatography; TOF, time of flight.