Table 1. Percentage of subjects who developed HIV-associated TB during longitudinal follow up according to antigen specificity of baseline IFN-γ responses.
Number of baseline IFN-γ responses | Antigen | n | Percent who developed TB |
Zero | None | 270 | 14% |
One | ESAT-6 | 4 | 25% |
Ag85 | 6 | 0% | |
WCL | 208 | 8% | |
Two | ESAT-6 + Ag85 | 1 | 0% |
WCL + ESAT-6 | 66 | 5% | |
WCL + Ag85 | 37 | 11% | |
Three | WCL + Ag85 + ESAT-6 | 114 | 4% |
Total | 706 | 9% |
Ag85, antigen 85; ESAT-6, early secreted antigenic target 6; IFN-γ, interferon gamma; TB, tuberculosis; WCL, whole cell lysate.