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. 2011 Jul 20;6(7):e22538. doi: 10.1371/journal.pone.0022538

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Bonetto et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A, p-STAT3 protein levels are increased in nuclear extracts prepared from quadriceps of severely cachectic C26 tumor-bearing mice compared to controls. n = 5 per group. B, Immunofluorescence analysis performed reveals increased pSTAT3 localization in myonuclei of gastrocnemius from severely cachectic C26 tumor-gearing mice (green). Nuclear staining is shown in blue (DAPI).