Table 1. Increased serum cytokines and acute phase response proteins with Colon-26 cachexia.
| Normal | Moderate Cachexia | Severe Cachexia | |
| gp130 Ligands | |||
| IL-6 (pg/ml) | <LOW> | 104±41*** | 120±22*** |
| IL-11 (pg/ml) | <LOW> | 2010±122*** | 3180±1424* |
| LIF (pg/ml) | 1570±170 | 1997±165* | 2137±172* |
| OSM (ng/ml) | <LOW> | 0.121±0.060* | 0.220±0.024*** |
| Other cachexia-associated cytokines | |||
| TNF (ng/ml) | <LOW> | 0.063±0.006* | 0.049±0.005* |
| IL-1α (pg/ml) | 62±17 | 204±90 | 214±0*** |
| IFN-γ (pg/ml) | <LOW> | 29±7.7** | 15±8** |
| Acute phase proteins | |||
| Fibrinogen (µg/ml) | 30,800±6,350 | 165,333±21,455** | 159,667±58,586*** |
| Haptoglobin (µg/ml) | 17±1.3 | 164±11.5*** | 173±20.1*** |
| Von Willebrand factor (ng/ml) | 75±36.7 | 322±49.7*** | 359±65.6** |
*P<0.05.
**P<0.01.
***P<0.001 versus normal. No differences between moderate and severe cachexia were statistically significant. <LOW> indicates below the level of detection.