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. 2011 Jul 20;6(7):e22538. doi: 10.1371/journal.pone.0022538

Table 3. Top 30 genes regulated in quadriceps in severe C26 cachexia.

Gene Gene Description p-value Fold Change
Nnat neuronatin 1.40E-05 −96.2
Cilp2 cartilage intermediate layer protein 2 0.0002 −39.4
Lcn2 lipocalin 2 0.007 33.1
Saa1 serum amyloid A 1 0.0107 33.0
Gm1611 gene model 1611, (NCBI) 0.0015 −32.9
Itih3 inter-alpha trypsin inhibitor, heavy chain 3 0.0004 29.9
Scgb3a1 secretoglobin, family 3A, member 1 0.0007 29.1
Rsph1 radial spoke head 1 homolog (Chlamydomonas) 1.50E-09 −28.4
Cxcl13 chemokine (C-X-C motif) ligand 13 0.0086 24.0
Lypd6 LY6/PLAUR domain containing 6 0.0044 −22.2
Aqp4 aquaporin 4 0.0024 −21.1
Myoz3 myozenin 3 0.008 −20.6
Plcd4 phospholipase C, delta 4 0.0389 −20.4
Actc1 actin, alpha, cardiac muscle 1 0.0004 −19.4
Kcng4 potassium voltage-gated channel, subfamily G, member 4 0.0006 −18.4
Rapgef6 Rap guanine nucleotide exchange factor (GEF) 6 0.0099 −18.1
Serpina3m serine (or cysteine) peptidase inhibitor, clade A, member 3M 0.0058 16.2
Csf2rb2 colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage) 0.0285 15.7
D0H4S114 DNA segment, human D4S114 0.0004 −15.7
Itih4 inter alpha-trypsin inhibitor, heavy chain 4 0.0001 15.7
Vsig4 V-set and immunoglobulin domain containing 4 0.0138 15.45
Mmd2 monocyte to macrophage differentiation-associated 2 0.0358 −15.4
Il1r2 interleukin 1 receptor, type II 0.0173 15.2
Pld5 phospholipase D family, member 5 0.0068 −13.9
Mt2 metallothionein 2 0.0184 13.9
Adamts4 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4 0.0003 13.0
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.0048 13.0
Gdap1 ganglioside-induced differentiation-associated-protein 1 0.0181 −12.6
3526401B18Rik RIKEN cDNA 3526401B18 gene 0.0048 −12.6
Chad chondroadherin 0.0023 −12.6