Peritoneal exudates cells (PEC) harvested from day 7, IOE infected WT and IL-18Rα-/- mice were cultured in vitro in the presence of IOE Ags for 48 hours. Peritoneal cell culture supernatant (A-D) and sera (E-H) collected on day 7 p.i. from all infected mice were tested for IL-6, TNF-α, IFN-γ, and IL-10, using ELISA. The data are expressed as the mean ± SEM for three mice in each group. The data shown are from one experiment and are representative of three different experiments. . *P <0.05, **P< 0.01. ***P< 0.001.