Table 2.
Hemodynamic variables before and after vasopressin (3 units bolus followed by 3 units/hour) in all patients (responders and non-responders) with end-stage liver disease undergoing liver transplantation who received vasopressin (p-value: compared to baseline values)
| Baseline | 0 min | 1 min | 3 min | 5 min | 10 min | 15 min | 20 min | ANOVA Post-test | |
|---|---|---|---|---|---|---|---|---|---|
| Pulse -/min | 76 +/− 18 | 75 +/− 16 ns |
75 +/− 16 ns |
71 +/− 14 p=0.002 |
71 +/− 14 p=0.001 |
73 +/− 15 p=0.03 |
75 +/− 16 ns |
75 +/− 16 ns |
p<0.0001 ns |
| Syst. BP - mmHg | 111 +/− 18 | 113 +/− 17 ns |
129 +/− 23 p=0.0001 |
141 +/− 27 p=0.0001 |
134 +/− 24 p=0.0001 |
124 +/− 21 p=0.0007 |
122 +/− 22 p=0.008 |
119 +/− 23 ns |
p<0.0001 p=0.03 |
| Mean BP – mmHg | 80 +/− 14 | 81 +/− 13 ns |
94 +/− 17 p=0.0001 |
102 +/− 19 p=0.0001 |
97 +/− 17 p=0.0001 |
88 +/− 15 p=0.003 |
88 +/− 14 p=0.01 |
87 +/− 15 ns |
p<0.0001 p=0.01 |
| Diast. BP – mmHg | 59 +/− 12 | 60 +/− 12 ns |
70 +/− 16 p=0.0005 |
76 +/− 16 p=0.0001 |
71 +/− 14 p=0.0001 |
66 +/− 12 p=0.004 |
65 +/− 11 p=0.01 |
65 +/− 12 p=0.03 |
p<0.0001 p=0.03 |
| Syst. PAP – mmHg | 28 +/− 6 | 29 +/− 6 p=0.03 |
31 +/− 7 p=0.002 |
35 +/− 9 p=0.0001 |
34 +/− 8 p=0.0001 |
32 +/− 8 p=0.007 |
31 +/− 9 ns |
29 +/− 9 ns |
p<0.0001 ns |
| Mean PAP – mmHg | 20 +/− 5 | 21 +/− 6 ns |
22 +/− 7 p=0.001 |
26 +/− 7 p=0.0001 |
26 +/− 6 p=0.0001 |
23 +/− 7 p=0.0001 |
22 +/− 7 ns |
21 +/− 8 ns |
p<0.0001 p=0.01 |
| Diast PAP – mmHg | 14 +/− 5 | 15 +/− 5 ns |
16 +/− 6 p=0.01 |
19 +/− 5 p=0.0001 |
19 +/− 6 p=0.0001 |
17 +/− 5 p=0.0008 |
16 +/− 6 ns |
15 +/− 6 ns |
p<0.0001 p=0.005 |
| CVP – mmHg | 9.6 +/− 4.3 | 10.2 +/− 4.5 ns |
12.2 +/− 3.5 p=0.002 |
12.9 +/− 4.5 p=0.0001 |
13.3 +/− 4.9 p=0.0001 |
12.3 +/− 4.6 p=0.0001 |
11.3 +/− 4.7 p=0.01 |
10.9 +/− 5.5 p=0.03 |
p<0.0001 p<0.0001 |
| CI - L/min/m2 | 3.55 +/− 1.27 | 3.2 +/− 1.2 ns |
3.6 +/− 1.4 ns |
3.5 +/− 1.4 ns |
3.4 +/− 1.3 ns |
3.4 +/− 1.4 ns |
3.6 +/− 1.6 ns |
3.5 +/− 1.5 ns |
ns |
| SVRI - dyn·s/cm5/m2 | 499 +/− 257 | 552 +/− 273 ns |
591 +/− 347 p=0.002 |
685 +/− 350 p=0.0005 |
668 +/− 363 p=0.001 |
615 +/− 379 p=0.02 |
588 +/− 417 ns |
622 +/− 412 p=0.048 |
p<0.0001 p<0.0001 |
| MAP/mPAP ratio | 4.4 +/− 1.5 | 4.4 +/− 1.2 ns |
4.2 +/− 1.1 ns |
4.0 +/− 1.1 ns |
4.1 +/− 1.2 ns |
4.2 +/− 1.4 ns |
4.5 +/− 1.5 ns |
4.9 +/− 2.0 ns |
p=0.016 ns |
| SvO2 - % | 84.1 +/− 8.4 | 84.1 +/− 6.9 ns |
86.0 +/− 6.6 ns |
85.2 +/− 6.9 ns |
84.3 +/− 8.3 ns |
84.1 +/− 8.3 ns |
84.5 +/− 8.8 ns |
82.6 +/− 10.1 ns |
ns |
| g-pCO2 - mmHg | 43.8 +/− 8.4 | 43.1 +/− 8.6 ns |
41.9 +/− 8.1 ns |
43.2 +/− 7.7 ns |
44.1 +/− 8.1 ns |
46.1 +/− 9.8 p=0.003 |
45.8 +/− 10.2 p=0.006 |
46.8 +/− 10.0 p=0.005 |
p<0.0001 p<0.0001 |
Abbreviations:
Min - minutes
BP – blood pressure
Syst. – systolic blood pressure
Diast. – diastolic blood pressure
CVP – central venous pressure
CO – cardiac output
CI – cardiac index
SVR – systemic vascular resistance
SVRI - systemic vascular resistance index
MAP/mPAP ratio – ratio of mean arterial pressure and mean pulmonary artery pressure
SvO2 – mixed venous oxygen saturation
g-pCO2 –gastric mucosal carbon dioxide partial pressure
ANOVA –repeated measure analysis of variance
Post test - post-hoc test for linear trend