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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: J Immunol. 2011 Jun 24;187(3):1506–1513. doi: 10.4049/jimmunol.1004142

Figure 6.

Figure 6

Effects of triple therapy on the survival and proteinuria of nephritic Ad-IFNα treated NZB/W F1 mice. A: Survival of the mice treated with a regular or low dose of Ad-IFNα alone, or together with triple therapy. Triple therapy was started upon proteinuria onset. p = 0.0308, regular dose Ad-IFNα treated mice with vs. without triple therapy; p =0.0014, low dose Ad-IFNα treated mice with vs. without triple therapy. B: Percentage of mice in which complete remission was induced by triple therapy. Complete remission is defined as proteinuria ≤ 30mg/dL for at least one week. Data are pooled from three representative experiments with a total of 15–34 mice per group. C: Renal glomerular damage and interstitial inflammation in triple therapy treated mice and Ad-IFNα only controls. Median + interquartile range shown. The mice that died before tissue could be harvested were assigned a histological score of 4 for statistical analysis. p values are compared with Ad-IFNα only controls. **: p < 0.02, †: p < 0.01.