Table II.
Number of spleen cell subsetsa
| No. of cells per spleen (mean ± SD) | CTLA4Ig (n=5) | CTX (n=5) | α-CD40L ab (n=5) | CTX/CTLA4Ig (n=5) | Triple therapy (n=6) | IFNα (n=8) |
|---|---|---|---|---|---|---|
| Total cell no. × 107 | 15.5 ± 3.6 | 13.4 ± 3.9 | 12.1 ± 1.9 | 10.2 ± 2.5 | 11.0 ± 2.7 | 16.3 ± 5.7 |
| CD19 × 107 | 6.5 ± 1.4 | 5.7 ± 1.6 | 5.3 ± 0.9 | 5.4 ± 1.5 | 3.8 ± 1.0 b | 8.7 ± 2.8 |
| CD19/CD69 × 106 | 4.4 ± 2.0 | 3.2 ± 2.1 | 2.8 ± 0.4 | 0.9 ± 0.3 b | 1.8 ± 1.2 c | 4.9 ± 2.7 |
| Follicular × 107 | 4.1 ± 0.9 | 2.5 ± 0.4 c | 2.9 ± 0.2 | 2.9 ± 1.1 d | 1.6 ± 0.5 b | 4.8 ± 1.8 |
| MZ × 106 | 3.8 ± 1.4 | 8.3 ± 3.2 | 4.5 ± 1.1 | 10.8 ± 3.8 | 9.1 ± 3.1 | 9.4 ± 2.7 |
| IgM−/IgD− × 106 (switched) | 6.3 ± 1.5 | 7.7 ± 3.6 | 3.9 ± 2.5 d | 2.6 ± 1.1 b | 0.7 ± 0.3 b | 8.2 ± 2.5 |
| CD4 × 107 | 4.9 ± 0.6 | 4.1 ± 1.2 | 3.9 ± 0.5 | 2.4 ± 0.5 | 3.2 ± 0.5 | 4.6 ± 2.4 |
| CD4/CD69 × 107 | 1.0 ± 0.5 | 0.8 ± 0.2 | 0.5 ± 0.2 | 0.2 ± 0.1b | 0.2 ± 0.1 b | 1.1 ± 0.6 |
| CD4/CD44+/CD62L− (memory) × 107 | 2.2 ± 1.0 | 1.7 ± 0.4 | 1.3 ± 0.5 c | 1.2 ± 0.3 b | 0.9 ± 0.3 b | 3.0 ± 1.8 |
| CD4/CD44−/CD62L+ (naive) × 107 | 2.0 ± 1.3 | 1.7 ± 1.0 | 2.1 ± 0.5 | 0.8 ± 0.3 | 1.8 ± 0.9 | 0.9 ± 1.1 |
| CD8 × 107 | 1.5 ± 1.1 | 1.8 ± 0.8 | 1.6 ± 0.2 | 1.1 ± 0.5 | 2.0 ± 0.8 | 1.3 ± 0.5 |
a
p values are compared with untreated Ad-IFNα pretreated controls. Only significant p values are shown.
b
p < 0.01;
c
p < 0.02;
d
p < 0.05.