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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: J Immunol. 2011 Jun 24;187(3):1393–1402. doi: 10.4049/jimmunol.1100980

Figure 4. In vivo cytotoxicity.

Figure 4

CTL response in HLA-A2tg mice against ML1419c p113-121 as detected by lysis of ML1419c p113-121-pulsed, CFSEhigh labeled syngeneic target cells using flow cytometry. The y-axis indicates the number of cells and the x-axis the CFSE intensity. The figure shows one representative CpG-immunized animal (A; n = 5), three representative animals from the groups immunized with ML1419c p113-121/CpG (B; n = 5) and ML1419c p100-129/CpG (C; n =5). Results shown are representative for at least four separate experiments. Correlation of ML1419c p113-121-specific in vivo lysis in various experiments with the percentage of HLA-A2/p113 TM+ CD8+ T-cells directly ex vivo (D) or after in vitro peptide restimulation (E).