TABLE I. ML1419c 9mer, 15mer and 30mer peptides.
Peptide | amino acid sequence | HLA-A*0201 binding affinity (IC50)* | in vivo CTL induction |
---|---|---|---|
ML1419c p113–121 | RLDGTTLEV | 0.035 μM | ++ |
ML1419c p108–122 | EAVLLRLDGTTLEVE | > 50 μM | + |
ML1419c p100-129 | VGDASQPS EAVLLRLDGTTLEVEAVSVLTV | > 50 μM | + |
Rv1886 p143-152 | FIYAGSLSAL | 0.01 μM | - |
Peptide binding affinity (IC50) was defined as high-affinity (< 1 μM), intermediate-affinity (1 μM to 10 μM), weak-affinity (10 μM to 100 μM), or nonbinding (>100 μM), according to reference (46).