Table 3.
Pathways over-represented amongst loci whose methylation was significantly associated with second hand smoking exposure
| Pathway | Type of second hand smoke exposure |
p-value | Genes |
|---|---|---|---|
| Non-Small Cell Lung Cancer Signaling | Adulthood | 0.004 | FHIT, NRAS, ITPR3, TGFA |
| Thyroid Cancer Signaling | Adulthood | 0.014 | PPARG, NRAS, RET |
| JAK/Stat Signaling | Adulthood | 0.020 | PTPN6, NRAS, TYK2 |
| IL-4 Signaling | Adulthood | 0.023 | PTPN6, NRAS, TYK2 |
| Renin-Angiotensin Signaling | Adulthood | 0.040 | PTPN6, NRAS, ITPR3 |
| ERK5 Signaling | Childhood | 0.036 | LIF, RRAS |
| Glioma Signaling | Childhood | 0.048 | RRAS, IGF2R |
| T Cell Receptor Signaling | Childhood | 0.048 | SHB, RRAS |
| Hepatic Fibrosis / Hepatic Stellate Cell Activation | Occupational | 0.027 | CTGF, FLT1 |
| JAK/Stat Signaling | Total | 0.033 | PTPN6, JAK2 |
| Growth Hormone Signaling | Total | 0.034 | PTPN6, JAK2 |
| Erythropoietin Signaling | Total | 0.035 | PTPN6, JAK2 |
| IL-4 Signaling | Total | 0.036 | PTPN6, JAK2 |
| IL-3 Signaling | Total | 0.037 | PTPN6, JAK2 |
| CTLA4 Signaling in Cytotoxic T Lymphocytes | Total | 0.046 | PTPN6, JAK2 |