Skip to main content
. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: J Immunol. 2011 Jun 22;187(3):1113–1119. doi: 10.4049/jimmunol.1100056

Figure 3. Blockade of PDL1: B7.1 pathway leads to enhanced cardiac allograft vasculopathy in the single MHC class II-mismatched transplant model.

Figure 3

The hearts from bm12 mice were transplanted into B6 WT recipients and treated with 2H11 anti-PDL1 mAb, which exclusively blocks PDL1: B7.1 pathway. (A) 2H11 treatment significantly increased vasculopathy score by 56 days after transplantation as compared with no treatment. ISHLT grade was also increased, although differences did not reach statistical significance. Values shown represent mean ± SEM histological score obtained from 3 individual mice. (B) Representative photomicrographs of elastin staining show advanced vasculopathy in 2H11-treated allografts. Bars, 200 μm.