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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: J Immunol. 2011 Jun 22;187(3):1113–1119. doi: 10.4049/jimmunol.1100056

Figure 6. PDL1: B7.1 blockade decreases CD4+CD25+Foxp3+ regulatory T cells in spleens of B6 recipients of bm12 hearts without affecting effector T cells.

Figure 6

FACS analysis of splenocytes from B6 recipients of bm12 hearts with or without 2H11 treatment at 10 -14 days post-Tx showed that 2H11 treatment resulted in a significantly lower percentage of CD4+CD25+Foxp3+ regulatory T cells than controls (A). The percentage of CD4+ and CD8+ effector/memory phenotype (CD44highCD62Llow) was similar between the 2H11-treated and control recipients (B and C). Bar graphs show means ±SEM. All results are representative of at least three different sets of experiments.