TABLE I.
Cases of Likely Monozygotic Twins with Van der Woude Syndrome in the Literature
| Zygosity/ Zygosity Testing | Presentation | |
|---|---|---|
| Cervenka et al, 1967 | Monozygotic/ Zygosity determined by examination of features and blood group | Lip pits in both, CL in one |
| Hersh and Verdi, 1992 | Monozygotic/ DNA linkage analysis | Unilateral CL/P, lip pits and natal tooth in both |
| Kondo et al., 2002 | Monozygotic/ Tested with microsatellite markers | One twin with the condition due to a new mutation, one twin without the mutation |
| Tokat et al., 2005 | Monozygotic/ No information on testing | Lip pits in both, CL in one, CP in one |
| Vignale et al., 1998 | Unknown | Unilateral CL and lip pits in both |