. Author manuscript; available in PMC: 2012 Jul 1.

Published in final edited form as: Mol Cancer Res. 2011 Jun 10;9(7):834–844. doi: 10.1158/1541-7786.MCR-10-0457

CD24^hi on the formation of brain metastases compared to unsorted 231-BR cells^*.

Group	Incidence	Mean Micrometastases (Median: Range)	Mean Macrometastases (Median: Range)
Unsorted 231-BR	7/11	73.3 (70.5: 44-135)	27.7 (20: 2-48)
CD44^hi/CD24^lo	5/9	59.4 (65: 28-119)	29.9 (30: 8-54)
CD44^lo/CD24^hi	10/10	44.5 (50: 8-79)^*	16.2 (17: 1-29)^**

Data shown were pooled from three independent experiments. 1.75 × 10⁵ cells (sorted and unsorted) were injected in nude mice via the intracardiac route. Mice were sacrificed 28 days later and brains were removed for histological analysis. Numbers shown are average values from 3 sections per mouse (median value and range also displayed). CD44^lo/CD24^hi formed fewer micrometastases and macrometastases when compared to CD44^hi/CD24^lo or unsorted 231-BR cells. Data was analyzed using Kruskal Wallis test

p < 0.05

^**

p < 0.001.

Table 1. In vivo analysis of the effect of sorting for CD44hi/CD24lo and CD44lo/CD24hi on the formation of brain metastases compared to unsorted 231-BR cells*.

Table 1. In vivo analysis of the effect of sorting for CD44^hi/CD24^lo and CD44^lo/CD24^hi on the formation of brain metastases compared to unsorted 231-BR cells^*.