Table II.
Risk of basal cell carcinoma (BCC) of the skin and squamous cell carcinoma (SCC) of the skin and use of NSAIDs and other analgesics
| Control | BCC | SCC | |||
|---|---|---|---|---|---|
| N | N | OR (95%CI)* | N | OR (95%CI)* | |
| NSAIDs | |||||
| No | 283 | 308 | 1.00 (ref) | 349 | 1.00 (ref) |
| Yes | 179 | 179 | 0.91 (0.69-1.21) | 186 | 0.78 (0.59-1.03) |
| Yes, current use | 137 | 133 | 0.89 (0.65-1.22) | 144 | 0.77 (0.57-1.05) |
| Yes, past use | 42 | 46 | 0.99 (0.62-1.58) | 42 | 0.80 (0.50-1.29) |
| Duration ≤ 6yrs | 83 | 92 | 0.99 (0.69-1.41) | 89 | 0.78 (0.54-1.11) |
| Duration > 6yrs | 96 | 87 | 0.83 (0.58-1.19) | 96 | 0.77 (0.55-1.10) |
| Aspirin | |||||
| No | 338 | 377 | 1.00 (ref) | 411 | 1.00 (ref) |
| Yes | 124 | 110 | 0.81 (0.59-1.12) | 124 | 0.75 (0.55-1.02) |
| Yes, current use | 100 | 85 | 0.79 (0.55-1.13) | 100 | 0.71 (0.51-1.01) |
| Yes, past use | 24 | 25 | 0.90 (0.49-1.66) | 24 | 0.87 (0.47-1.62) |
| Duration ≤ 6yrs | 60 | 51 | 0.77 (0.50-1.18) | 55 | 0.66 (0.43-1.00) |
| Duration > 6yrs | 64 | 58 | 0.88 (0.58-1.35) | 68 | 0.82 (0.55-1.23) |
| Propionic acid NSAIDs | |||||
| No | 450 | 469 | 1.00 (ref) | 520 | 1.00 (ref) |
| Yes | 12 | 18 | 1.51 (0.66-3.44) | 15 | 1.19 (0.51-2.79) |
| Yes, current use | 8 | 13 | 1.43 (0.54-3.78) | 7 | 0.88 (0.29-2.61) |
| Yes, past use | 4 | 5 | 1.71 (0.37-7.85) | 8 | 1.91 (0.47-7.76) |
| Duration ≤ 3yrs | 8 | 6 | 0.81 (0.25-2.63) | 6 | 0.78 (0.22-2.70) |
| Duration > 3yrs | 4 | 12 | 2.68 (0.81-8.88) | 9 | 1.75 (0.52-5.90) |
| Ibuprofen | |||||
| No | 405 | 419 | 1.00 (ref) | 472 | 1.00 (ref) |
| Yes | 57 | 68 | 1.05 (0.70-1.56) | 63 | 0.91 (0.61-1.35) |
| Yes, current use | 29 | 39 | 1.13 (0.66-1.94) | 41 | 1.13 (0.67-1.91) |
| Yes, past use | 28 | 29 | 0.97 (0.56-1.69) | 22 | 0.68 (0.38-1.24) |
| Duration ≤ 4yrs | 25 | 33 | 1.18 (0.68-2.05) | 33 | 1.01 (0.58-1.76) |
| Duration > 4yrs | 32 | 35 | 0.94 (0.55-1.61) | 30 | 0.83 (0.48-1.42) |
| Paracetamol | |||||
| No | 403 | 438 | 1.00 (ref) | 490 | 1.00 (ref) |
| Yes | 59 | 49 | 0.65 (0.42-1.01) | 45 | 0.62 (0.40-0.97) |
| Yes, current use | 40 | 30 | 0.56 (0.33-0.97) | 31 | 0.56 (0.33-0.97) |
| Yes, past use | 19 | 19 | 0.82 (0.41-1.63) | 14 | 0.72 (0.34-1.50) |
| Duration ≤ 7yrs | 30 | 26 | 0.74 (0.42-1.32) | 19 | 0.51 (0.27-0.97) |
| Duration > 7yrs | 29 | 23 | 0.54 (0.29-1.03) | 25 | 0.68 (0.37-1.23) |
*
OR adjusted for age, gender, number of cigarettes smoked per day, skin type, lifelong number of painful sunburns and lifelong cumulative number of hours of sun exposure
*
P-values are <.05 if the 95% CI does not include the value of 1