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PIs specify membrane identity in epithelial cells. PI(3)-kinase generated PIP3 (PtdIns(3,4,5)P3) at the basolateral surface contributes to apico-basal polarity specification. This is coordinated with PTEN and PI(5)-kinase enrichment of PIP2 (PtdIns(4,5)P2) at the apical surface. A PTEN/PIP2/Anx2/Cdc42 pathway links the production of PIP2 to actin reorganization during apical membrane biogenesis and lumen formation.
