Table 3.
Clinical and pathological features in carriers and noncarriers of 17q CaP sequence variants in recessive best fit genetic model
| 17q12 | 17q24 | ||||||
|---|---|---|---|---|---|---|---|
| No. Pts | Carriers (TT) | Noncarriers (CT or CC) |
p Value* | Carriers (G,G) | Noncarriers (G,T or T,T) |
p Value* | |
| Median age (range) | 759 | 59 (41–75) | 59 (37–77) | 0.89 | 59 (37–77) | 59 (39–77) | 0.75 |
| Median ng/ml preop PSA (range) | 727 | 5.0 (0.5–48.0) | 5.0 (0.3–30.0) | 0.71 | 5.1 (0.8–48.0) | 5.0 (0.3–39.4) | 0.92 |
| Median ng/ml/yr PSA velocity (range) | 313 | 1.2 (−45.0–19.4) | 1.6 (−251.4–37.3) | 0.07 | 1.4 (−8.1–19.4) | 1.4 (−251.4–37.3) | 0.57 |
| No. family history 1st-degree relative (%) | 652 | 55 (27) | 142 (32) | 0.17 | 50 (28) | 147 (31) | 0.57 |
| No. stage ≤T1C (%) | 728 | 151 (65) | 364 (73) | 0.04 | 142 (70) | 373 (71) | 0.79 |
| No. biopsy Gleason score ≥7 (%) | 711 | 73 (32) | 158 (33) | 0.93 | 71 (36) | 160 (31) | 0.21 |
| No. pathological Gleason score ≥7 (%) | 707 | 110 (49) | 241 (50) | 0.87 | 88 (46) | 263 (51) | 0.24 |
| No. organ confined T2 (%) | 724 | 184 (81) | 392 (79) | 0.62 | 159 (80) | 417 (80) | 0.99 |
| No. extracapsular extension (%) | 711 | 42 (19) | 95 (20) | 0.84 | 36 (18) | 101 (20) | 0.75 |
| No. pos surgical margins (%) | 725 | 45 (20) | 90 (18) | 0.68 | 42 (21) | 93 (18) | 0.34 |
| No. seminal vesicle invasion (%) | 725 | 8 (3) | 26 (5) | 0.35 | 10 (5) | 24 (5) | 0.84 |
| No. pos lymph nodes (%) | 723 | 2 (1) | 4 (1) | 0.99 | 3 (2) | 3 (1) | 0.36 |
| No. biological recurrence (%)** | 397 | 10 (9) | 16 (6) | 0.18 | 3 (3) | 23 (8) | 0.16 |
*
Kruskal-Wallis test for continuous variables, eg age, PSA and PSA velocity, and Fisher’s exact test for categorical variables.
**
PSA greater than 0.2 ng/ml