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. Author manuscript; available in PMC: 2012 Oct 10.
Published in final edited form as: Behav Brain Res. 2011 Jun 6;224(1):166–173. doi: 10.1016/j.bbr.2011.05.038

Fig. 1.

Fig. 1

Effect of neonatal LPS-exposure on METH-induced locomotor activity, as determined by the total distance traveled in the open field test in the P70 male (A) and female (B) rats. A & B, average values for the distance traveled by the P70 rats after saline or METH (0.5 mg/kg) treatment. Each point represents the cumulative distance (cm) traveled in 10-min intervals for a total duration of 150 min. C, bar graphs represent the average values for the distance traveled by P70 rats in specific time intervals from 0 to 60 min, 61 to 120 min, and 0 to 120 min, after saline or METH (0.5 mg/kg) treatment. The results are expressed as the mean±SEM of five animals in each group and analyzed by two-way repeated measures ANOVA for data from tests conducted continuously at different experimental times or by two-way ANOVA for the behavioral response in the specific time intervals followed by Student-Newman-Keuls test. * P<0.05 represents significant difference for the saline+METH group as compared with that of the saline+saline group. # P<0.05 represents significant difference for the LPS+METH group as compared with that of the LPS+saline group. & P<0.05 represents significant difference for the LPS+METH group as compared with that of the saline+METH group.