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. Author manuscript; available in PMC: 2012 Oct 10.
Published in final edited form as: Behav Brain Res. 2011 Jun 6;224(1):166–173. doi: 10.1016/j.bbr.2011.05.038

Fig. 2.

Fig. 2

Effect of neonatal LPS-exposure on METH-induced behaviors sensitization (from P70 to P74) and reinstated behavioral sensitization (P78), as determined by the total distance traveled in the open field test in the male (B) and female (C) rats. A, treatment procedure. Repeated administration of METH in rats developed behavioral sensitization as indicated by the progressively increased behavioral response of the total distance traveled as compared with the data of day 1 (P70). After 5 injections from P70 to P74 (day 1 to day 5), animals received a single injection of saline or METH after ninety-six hour drug abstinence from the 5th injection of METH to assess the reinstated behavioral sensitization (P78, day 9). Each point represents the cumulative distance (cm) traveled for a total duration of 120 min on the different experimental day. The results are expressed as the mean±SEM of five animals in each group and analyzed by two-way repeated measures ANOVA for data from tests conducted continuously at different experimental day followed by Student-Newman-Keuls test. * P<0.05 represents significant difference for the experimental day as compared with the data of day 1 in the saline+METH group. # P<0.05 represents significant difference for the experimental day as compared with the data of day 1 in the LPS+METH group. & P<0.05 represents significant difference for the LPS+METH group as compared with that of the saline+METH group in the same experimental day. $ P<0.05 represents significant difference for the day 9 as compared with the data of day 5 in the saline+METH or LPS+METH group.