Table 2.

Pharmacokinetic parameters^a and the half clearance time of radioactivity^b from the blood pool in mice

Liposomes	t1/2c (h)	VDd (mL)	AUCe0-24h (%ID/cc hr)	CLf (mL/h)
In vivo
64Cu-DSPE liposomes (n = 4)	18.46	3.41	646.9	0.102
64Cu-DPPE liposomes (n = 8)	5.093	3.60	277.3	0.445
64Cu-DSPE-1mol% DPPC liposomes (n = 4)	19.40	4.64	707.4	0.153
In vitro
64Cu-DPPE liposomes	7.857g n/a		n/a	n/a

^apharmacokinetic parameters are derived from Figure 5a and b as described further in the supplement

^bthe half clearance times were obtained from one phase exponential decay curve fit (Y = A e^−k×t).

^chalf clearance time

^dvolume of distribution

^earea under curve at 24 hours

^fclearance from animal

^ghalf clearance was calculated based on Figure 5d (in vitro) by one-phase exponential decay curve fit (Y = A e^−k×t).