TABLE 1.
Microtomographic bone morphometry of the proximal tibia
| Genotype | BV/TV (%) | BS/BV (1/mm) | Tb.Th (μm) | Tb.N (1/mm) | Tb.Sp (μm) | C.Th (μm) | BMD (mg/cc) | SW/SLa | HW/HLa |
|---|---|---|---|---|---|---|---|---|---|
| Δ/Δ | 18.0 ± 4.0* | 115 ± 25* | 19.0 ± 6.0* | 8.8 ± 1.8* | 100.0 ± 20.0* | 60.0 ± 10.0* | 139 ± 25* | 0.85 ± 0.05* | 0.48 ± 0.04* |
| +/Δ | 30.0 ± 5.0 | 84.1 ± 12 | 29.0 ± 4.0 | 12.8 ± 0.7 | 60.0 ± 20.0 | 90.0 ± 10.0 | 194 ± 24 | 0.71 ± 0.05 | 0.41 ± 0.03 |
| +/+ | 32.0 ± 2.0 | 86.2 ± 15 | 28.0 ± 4.0 | 13.8 ± 0.8 | 50.0 ± 20.0 | 100.0 ± 20.0 | 201 ± 28 | 0.73 ± .05 | 0.40 ± 0.03 |
Morphometry at d 5 (n=4). BV/TV, bone volume/total volume; BS/BV, bone surface area/bone volume; Tb.Th, trabecular thickness; Tb.N, trabecular number; Tb.Sp, trabecular spacing; C.Th, cortical wall thickness; BMD, bone mineral density; SW/SL, scapular width (cranial to caudal angles) to length ratio; HW/HL, humeral width (at the distal growth plate) to length ratio (Figure 2).
a
Higher number indicates shorter bones.
*
P < 0.05.