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. Author manuscript; available in PMC: 2012 Mar 15.
Published in final edited form as: Clin Cancer Res. 2010 Dec 21;17(6):1362–1372. doi: 10.1158/1078-0432.CCR-10-2213

Figure 6. OV-Chase infection reduces glioma cell dispersion in vitro and does not affect tumor spread in vivo.

Figure 6

A) Spheroids of LN229 glioma cells were treated with PBS, rHsvQ or OV-Chase and embedded in collagen as indicated in the methodology. The images show representative bright-field and fluorescent images revealing total spheroid dispersal (bright-field) and total viral spread in the spheroid (scale bar = 500μm). B) Representative images of mouse brain sections bearing U87ΔEGFR glioma treated with PBS, rHsvQ or OV-Chase. The sections were stained with anti-human vimentin to highlight human glioma cells in mouse brain. Infiltrating human glioma cells are visualized as brown staining cells. There was no difference in invasion of glioma cells after treatment with PBS, rHsvQ or OV (Scale bar = 100μm).