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Ex vivo determination of BCNU sensitivitya
| Control | 1× (dose 1) | 2× (dose 1) | |
|---|---|---|---|
| IC50 ± SEM (µM) | 42 ± 5 | 54 ± 4 | 62 ± 1 |
| p (versus control) | — | >0.05 | <0.01 |
Cell lines from tumors excised from control, 1× treated and 2× treated animals were assayed using an SRB growth inhibition assay to determine sensitivity to BCNU. The calculated mean IC50 ± SE for control (n = 6), 1× (n = 3) and 2× (n = 3) are shown, and also p-values determined using a standard Student’s t-test.
