Table.

Subject demographics^a

Abbreviations: CDR-SB = Clinical Dementia Rating Scale Sum of Boxes; CI = confidence interval; MMSE = Mini-Mental State Examination; STMS = Short Test of Mental Status.

^aUnless otherwise indicated, values shown are median (range). Disease duration is calculated as time from onset to first MRI. Five subjects in GRN controls, 3 subjects in GRN, 4 subjects in MAPT controls, and 4 subjects in MAPT had only 2 serial MRI.

^bSignificant difference observed between the GRN and MAPT groups at p < 0.05.

^cSignificant difference observed between GRN and GRN controls at p < 0.05.

^dSignificant difference observed between MAPT and MAPT controls at p < 0.05.