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. 2011 May 19;20(16):3138–3150. doi: 10.1093/hmg/ddr216

Figure 2.

Figure 2.

Circulating LH and FSH are decreased in Chd7Gt/+ mice. (A) Chd7Gt/+ mice analyzed for circulating LH have decreased serum levels compared with wild-type littermates. The LH reportable range was 0.04–37.4 ng/ml. (B) Chd7Gt/+ females have decreased levels of circulating FSH but Chd7Gt/+ males have normal serum levels. The FSH reportable range was 2.3–20.0 ng/ml. (C and D) GnRH agonist, leuprolide, administered to wild-type and Chd7Gt/+ mice caused similar responses in the production and circulation of LH and FSH. The reportable range for LH was 0.04–37.4 ng/ml and for FSH was 6.7–75.0 ng/ml. (E and F) Wild-type and Chd7Gt/+ males were administered GnRH antagonist, antide. Wild-type and Chd7Gt/+ males have similar decreases in circulating levels of LH and FSH. The reportable range for LH was 0.04–37.4 ng/ml and for FSH was 6.7–75.0 ng/ml. **P < 0.01, ***P < 0.001 by unpaired Student's t-test. NS, not significant.